《绝情姐妹》Chatfah, the youngest sister of the Bupphachinda family, has just received the largest share of her father's inheritance and is about to be married. However, Chatfah falls from the highest floor of a vacation home to her three older sisters' shocked eyes. When her body disappears, her three sisters—Baibua, Chomphu, and Picha—become suspects in her disappearance.
The eldest sister Baibua is composed, wise, and has always sacrificed for her family. The second, Chomphu, is a confident model whose boyfriend Chatfah stole and was engaged to. The third, Putpichaya, is a jewellery designer and the closest to Chatfah. The three search for Chatfah while further tragedy befalls them following their youngest sister's disappearance.
When no one else can be trusted, the three sisters must try to trust one another. They move back to their childhood mansion to find out who was behind Chatfah's disappearance, which could very well be one of them.